643. Enhanced Distribution of LCMV-Pesudotyped Bicistronic Lentiviral Vector Containing a Recombinant HSV-TK and EGFRwt for Glioblastoma Treatment
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چکیده
منابع مشابه
construction of the recombinant lentiviral vector containing human gh1 gene and its expression in hek293t cells
human growth hormone (hgh) is a protein with multiple roles in a range of biological functions such as protein, carbohydrates and lipid metabolisms as well as immunity, tissue development and overall growth. one of the major class of biopharmaceuticals in mammalian cells is the production of recombinant pharmaceutical proteins. in this study, we constructed a lentiviral vector carrying coding r...
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In this study, in order to facilitate and accelerate the production of eukaryotic protein alpha 1-antitrypsin (AAT) with correct post-translational modifications, a protein production system based on the transduction of CHO and COS-7 cells using lentiviral vectors was developed. Human AAT cDNA was cloned into a replication-defective lentiviral vector. The transgene AAT-Jred chimer was transferr...
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چکیده ندارد.
15 صفحه اولRecombinant interleukin-2 enhanced the antitumor effect of ADV/RSV-HSV-tk/ACV therapy in a murine bladder cancer model.
BACKGROUND Previous studies demonstrated the antitumor effects of IL-2 and ADV/RSV-HSV-tk in bladder tumor models. In our study, we employed the intramuscular injection of recombinant IL-2 combined with ADV/RSV-HSV-tk gene therapy in the MBT-2 murine bladder tumor model. MATERIALS AND METHODS In the in vitro study, after adenoviral gene transduction efficiency had been assessed, the cytotoxic...
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ABSTRACT Introduction: Non-Hodgkin lymphoma (NHL) is a cancer that starts in lymphocytes. The main treatment for NHL is chemotherapy and radiation. Today immunotherapy is a promising therapeutic approach in the treatment of a variety cancers which is high specific unlike previous methods. Antibodies do not penetrate effectively into tumore tissues because of their large size. Whe...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2015
ISSN: 1525-0016
DOI: 10.1016/s1525-0016(16)34252-6